MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis

Figure 5 Serpin family E member 1 is a potential target gene of microRNA-145-5p and is highly expressed in gastric cancer tissues and cells. A: A Venn diagram of overlapping mRNAs from the differentially expressed mRNAs in The Cancer Genome Atlas (TCGA)-STAD data and miRNA-145-5p (miR-145-5p) target genes predicted from the two bioinformatics databases; B: Box diagram showing the differential expression of serpin family E member 1 (SERPINE1) in the normal and tumor data in TCGA-STAD; C: Overall survival curves of patients in the high (red) and low (blue) SERPINE1 expression groups; D: Differential expression of SERPINE1 mRNA (left panel) and protein (middle panel) in gastric cancer (GC) tissue and SERPINE1 mRNA (right panel) in the HGC27 and SGC7901 GC cell lines; scale bar = 20 μm; E: SERPINE1 mRNA and protein expression in the miR-145-5p mimic group in SGC7901 cells and the inhibitor group in HGC27 cells. ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001.