Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19

Figure 3 Comparisons. A: Comparison of transcription factors profile between peripheral blood mononuclear cells (PBMCs) isolated from colorectal cancer (CRC) patients with severe coronavirus disease 2019 and age-matched CRC patients (PBMCs-C); B: Comparison of T-box TF TBX21 (T-bet)/GATA binding protein 3 (GATA-3) and RAR-related orphan receptor C (RORC)/forkhead box P3 (FoxP3) ratio between PBMCs from CRC⁺ patients (PBMCs-C⁺) and PBMCs-C; C: Comparison of cytokines secretion profile in cell culture supernatants obtained from PBMCs-C⁺ and PBMCs-C; D: Comparison of interferon gamma (IFN-γ)/interleukin 4 (IL-4) and IL-17A/transforming growth factor beta one (TGF-β1) ratios between PBMCs-C⁺ and PBMCs-C; E: Comparison of transcription factors profile between PBMCs-C⁺/adipose tissue-derived mesenchymal stem cells (ADSCs) and PBMCs-C⁺; F: Comparison of T-bet/GATA-3 and RORC/FoxP3 ratio between PBMCs-C⁺/ADSCs and PBMCs-C⁺; G: Comparison of cytokine secretion profile in cell culture supernatants obtained from PBMCs-C⁺/ADSCs and PBMCs-C⁺; H: Comparison of IFN-γ/IL-4 and IL-17A/TGF-β1 ratios PBMCs-C⁺/ADSCs and PBMCs-C⁺. ^aP < 0.05, ^bP < 0.01 via Student's t-test.