Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion

Figure 6 Immune cell infiltration in the high and low plexin domain-containing 1 gene expression groups. A: Analysis of immune subtypes in hepatocellular carcinoma (HCC) immune cells with plexin domain-containing 1 (PLXDC1) expression in immune cells in the The Cancer Genome Atlas database; B: Immunohistochemical staining analysis of in 123 paraffin-embedded HCC samples showed that CD73 and CD134 expression levels were low when PLXDC1 expression was low, while CD3, CD4, and CD8 expression levels were low in tumor tissues with high PLXDC1 expression in the stroma; when CD73 and CD134 levels were high, PLXDC1 was also highly expressed; when CD3, CD4, and CD8 levels were low in the tumor tissue, PLXDC1 levels were high in the stroma. Orange arrows: Location of immune cells.