Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

Figure 3 The role of Schlafen-11 on DNA damage repair network in esophageal squamous cell carcinoma cells. A: The levels of Schlafen-11 (SLFN11), p-DNAPKcs, DNAPKcs, and XRCC4 under the treatment of 1 μmol/L cisplatin for 12 h and 24 h in KYSE30 and KYSE450 cells before and after SLFN11 re-expression and in KYSE510 before and after SLFN11 knockout; B: The effects on ATR/CHK1 signaling in KYSE30 and KYSE450 cells after SLFN11 re-expression and in KYSE510 cells after SLFN11 knockout under the treatment of 1 μmol/L cisplatin for 12 h and 24 h; C: The effects on ATM/CHK2 signaling in KYSE30 and KYSE450 cells after the restoration of SLFN11 and in KYSE510 cells after SLFN11 knockout under the treatment of 1 μmol/L cisplatin for 12 h and 24 h. β-actin: Internal control.