Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

Figure 2 Schlafen-11 was correlated with chemoresistance to cisplatin in esophageal squamous cell carcinoma cells. A: MTT assay showing the sensitivity to cisplatin in KYSE30 and KYSE450 cells before and after re-expression of Schlafen-11 (SLFN11), and in KYSE510 cells before and after knockout of SLFN11, data are representative of three independent experiments; B: Representative colony formation assay under the treatment of 1 μmol/L and 2 μmol/L cisplatin for 14 d in esophageal squamous cell carcinoma cells. Each experiment was repeated in triplicate. The average normalized colony efficiency was indicated by a bar diagram. Statistical significance was analyzed by t test (^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001). KO: Knockout; SLFN11: Schlafen-11.