Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

Figure 7 Schematic model illustrates the biological role of the miR-490-3p/heterogeneous ribonucleoprotein A1-b/PKM2 axis in colon cancer progression. The schematic shows that heterogeneous ribonucleoprotein A1 hnRNPA1-b promotes the selective expression of PKM2, enhances the Warburg effect through PI3K/AKT pathway, facilitates the proliferation and division of colon cancer (CC) cells, and hinders the apoptosis of CC cells. However, when miR-490-3p binds to hnRNPA1-b, it exerts an inhibitory effect on the aforementioned biological processes. hnRNPA1: Heterogeneous ribonucleoprotein A1.