SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway

Figure 1 Identification and characterization of serpin peptidase inhibitor clade H member 1 in colorectal cancer cells and tissues. A: Upregulated serpin peptidase inhibitor clade H member 1 (SERPINH1) mRNA expression in colorectal cancer (CRC) compared with normal colorectal tissue in The Cancer Genome Atlas (TCGA) database; B and C: Expression mRNA level; D and E: Kaplan-Meier analysis of overall survival and relapse-free survival of colorectal adenocarcinoma (COAD) patients with low vs high SERPINH1 expression from TCGA datasets; F and G: The relative expression of SERPINH1 protein and mRNA in normal human colon epithelial cells and seven CRC cell lines by western blotting and quantitative real-time polymerase chain reaction. mean ± SD (n = 3); H: Protein level of SERPINH1 in COAD (matched tissues and unmatched tissues); I: Protein expression level of SERPINH1 in normal tissues and CRC tissues from HPA; J: Kaplan-Meier survival analysis of the association between SERPINH1 expression and overall survival in 50 CRC patients. All the data are presented as the mean ± SEM. ^aP < 0.05, ^cP < 0.001. SERPINH1: Serpin peptidase inhibitor clade H member 1; CRC: Colorectal cancer; COAD: Colorectal adenocarcinoma.