Advances in the study of gastric organoids as disease models

Figure 3 Application of gastric organoid. The role of gastric organoids in observing the pathogenesis of gastric cancer caused by Helicobacter pylori (H. pylori): Used a microinjection method to inject H. pylori directly into the gastric epithelial organoid sphere. The role of gastric organoids in the study of microbe-host relationships: By co-culturing gastric organ tissues of individuals infected with H. pylori with host immune cells. Drug screening: Effectiveness, toxicity and drug resistance: In the process of drug screening and development, drug testing is necessary, including preclinical experiments and clinical trials. Organoid biobank: Referred to a specialized repository used for the preservation and study of various artificially synthesized organoids. Regenerative medicine and personalized therapy: Patient-derived xenografts organoids offer new possibilities for individualized therapy by culturing patient-derived tumor xenograft models in a way that preserves tumor properties and stem cell properties, representing a new tool for personalized therapy and regenerative medicine research. H. pylori: Helicobacter pylori.