Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis

Table 1 Univariate and multivariate Cox regression analyses of the ferroptosis-related genes prognostic index and other clinicopathologic factors for overall survival in the cancer genome atlas and GSE84426 cohorts

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
TCGA cohort
Age (≤ 65 vs > 65)	1.620 (1.154-2.276)	0.005	1.409 (0.943-2.105)	0.095
Gender (male vs female)	1.267 (0.891-1.804)	0.188
Pathologic stage (I&II vs III&IV)	1.947 (1.358-2.793)	< 0.01	1.106 (0.614-1.991)	0.737
T stage (T1&T2 vs T3&T4)	1.719 (1.131-2.612)	0.011	1.386 (0.763-2.515)	0.283
N stage (N0 vs N1&N2&N3)	1.925 (1.264-2.931)	0.002	1.512 (0.776-2.944)	0.224
M stage (M0 vs M1)	2.254 (1.295-3.924)	0.004	1.406 (0.679-2.911)	0.359
Histologic grade (G1 vs G2&G3)	1.957 (0.484-7.910)	0.346
H. pylori infection	0.650 (0.279-1.513)	0.317
Primary therapy outcome (CR vs PD&SD&PR)	4.228 (2.905-6.152)	< 0.01	4.453 (2.973-6.672)	< 0.01
FRGPI (high risk vs low risk)	1.542 (1.105-2.152)	0.011	2.303 (1.531-3.467)	< 0.01
GSE84426
Age (≤ 65 vs > 65)	1.023 (0.993-1.053)	0.132
Gender (male vs female)	0.857 (0.401-1.830)	0.689
T stage (T1&T2 vs T3&T4)	1.392 (0.668-2.900)	0.677
N stage (N0 vs N1&N2&N3)	1.010 (0.356-2.862)	0.986
FRGPI (high risk vs low risk)	2.001 (1.000-3.001)	< 0.01	2.001 (1.20-3.501)	< 0.01

FRGPI: Ferroptosis-related genes prognostic index; CR: Complete response; PR: Partial Response; PD: Progressive disease; SD: Stable disease.