Casual associations between blood metabolites and colon cancer

Table 2 Odds ratios and 95%CI of associations between metabolites and the risk of colorectal cancer in sensitivity analysis

Metabolites	Maximum likelihood		MR-RAPS		MR-egger intercept
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Mannose	2.10 (1.10-4.02)	0.024	2.10 (1.10-4.03)	0.025	1.02 (0.97-1.08)	0.500
Arachidonate (20:4n6)	3.19 (1.79-5.68)	8.48 × 10-5	3.19 (1.79-5.69)	8.60 × 10-5	0.99 (0.90-1.10)	0.868
Tyrosine	0.08 (0.01-0.63)	0.016	0.08 (0.01-0.67)	0.019	0.93 (0.74-1.15)	0.491
Urate	0.25 (0.10-0.62)	0.003	0.25 (0.10-0.62)	0.003	1.01 (0.97-1.05)	0.586
N-acetylglycine	0.73 (0.54-0.98)	0.034	0.73 (0.54-0.98)	0.036	0.97 (0.94-1.00)	0.095
X-11593-O-methylascorbate	1.72 (1.06-2.80)	0.028	1.69 (1.04-2.76)	0.034	1.00 (0.97-1.02)	0.871
1-arachidonoylglycerophosphocholine	4.26 (2.49-7.27)	1.13 × 10-7	4.26 (2.48-7.31)	1.47 × 10-7	0.98 (0.95-1.02)	0.365
X-12092	0.89 (0.81-0.99)	0.027	0.89 (0.81-0.99)	0.028	1.00 (0.98-1.02)	0.952
1-arachidonoylglycerophosphoethanolamine	4.13 (1.91-8.91)	3.04 × 10-4	4.13 (1.92-8.86)	2.76 × 10-4	0.98 (0.88-1.10)	0.756
Succinylcarnitine	0.48 (0.27-0.84)	0.011	0.47 (0.27-0.84)	0.010	1.02 (0.99-1.04)	0.181

MR: Mendelian randomization; MR-RAPS: Mendelian randomization robust adjusted profile score; OR: Odds ratios.