Correlation of tumor-associated macrophage density and proportion of M2 subtypes with the pathological stage of colorectal cancer

Table 2 Tumor-associated macrophage distribution

Population	Tumor stroma	Tumor front	P value1
Densities, median (IQR)
TAM (anti-CD68+)	32 (22-32)	40 (24-53)	0.00031
M2 (anti-CD163+)	21 (15-30)	29 (19-38)	0.00031
M1 (calculated)	7 (4-10)	8 (4-13)	0.0381
Proportion, %
M1	25	29	0.00012
M2	75	71
Ratio, median
M1	9.21 (± 8.98)	10.91 (± 9.36)	0.000013
M2	22.56 (± 9.7)	30 (± 14.86)

¹Wilcoxon signed-rank test of median difference in a nonparametric distribution;

²McNemar test of difference between paired proportions;

³Friedman’s two-way analysis of variance by rank.

TAMs: Tumor-associated macrophages.