Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection: A retrospective study

Table 2 Univariate and multivariate analyses for overall survival in the training cohort

Variables		Univariate analysis	P value	Multivariate analysis	P value
		HR (95%CI)		HR (95%CI)
Gender	Male	1	-	-	-
	Female	5.755 (0.660, 50.196)	0.033	-	-
Age	≥ 75	1.745 (0.198, 15.416)	0.064	-	-
	< 75	1	-	-	-
Obstruction	Yes	0.785 (0.035, 17.665)	0.014	-	-
	No	1	-	-	-
CEA (ng/mL)	> 5	1.576 (0.497, 4.994)	0.434	-	-
	≤ 5	1	-	-	-
CA199 (U/mL)	> 37	20.20 (1.881, 216.893)	0.002	6.315 (1.520, 26.243)	0.011
	≤ 37	1	-	1	-
Surgical procedure	Laparotomy	1.586 (0.130, 19.331)	0.012	-	-
	Laparoscopy	1	-	-	-
Right hemicolon	Yes	2.873 (0.775, 10.656)	0.016	5.236 (1.229, 22.308)	0.025
	No	1	-	1	-
Enterostomy	Yes	6.086 (1.949, 19.007)	0.000	13.302 (3.392, 52.171)	0.000
	No	1	-	1	-
Tumor size (cm)	≥ 6.8	2.252 (0.376, 13.489)	0.004	-	-
	< 6.8	1	-	-	-
Poor differentiated	Yes	4.311 (1.341, 13.856)	0.008	-	-
	No	1	-	-	-
T stage	T4a	1	-	1	-
	T4b	8.241 (2.500, 27.158)	0.000	10.888 (2.809, 42.199)	0.001
Lymph node count	≥ 12	1	-	-	-
	< 12	1.143 (0.250, 5.225)	0.863	-	-
Regular review	Yes	1	-	1	-
	No	5.676 (1.534, 21.000)	0.003	4.626 (1.075, 19.905)	0.040

CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199.