TRIANGLE operation, combined with adequate adjuvant chemotherapy, can improve the prognosis of pancreatic head cancer: A retrospective study

Table 3 Univariate and multivariate analyses of independent prognostic variables for different recurrence patterns

Variables	Total (n = 70)			Local (n = 21)			Distant (n = 34)			Local + distant (n = 15)
	P1	HR (95%CI)	P2	P1	HR (95%CI)	P2	P1	HR (95%CI)	P2	P1	HR (95%CI)	P2
Age (yr), > 70/≤ 70	0.206	-		0.092	-		0.864	-		0.470	-
Sex, male/female	0.572	-		0.304	-		0.866	-		0.707	-
PDTRIANGLE, +/-	< 0.001c	0.424 (0.256-0.702)	0.001b	0.002b	0.175 (0.059-0.521)	0.002b	0.649	-		0.011a	0.188 (0.052-0.683)	0.011a
Grading, 2-3/1
2	0.663	-		0.997	-		0.997	-		0.240	-
3	0.813	-		0.997	-		0.997	-		0.292	-
Margin status, R1/R0	0.031a	2.255 (1.252-4.064)	0.007b	0.249	-		0.346	-		0.066	-
AJCC stage (8th ed), I-IIa/IIb-III	0.057	-		0.801	-		0.077	-		0.038a	3.608 (1.057-12.308)	0.040a
PNI, +/-	0.427	-		0.887	-		0.478	-		0.512	-
PVI, +/-	0.064	-		0.694	-		0.036a	1.862 (0.940-3.691)	0.075	0.833
CA19-9, > 37.0/≤ 37.0	0.098	-		0.141	-		0.019a	5.684 (1.354-23.868)	0.018a	0.152	-
CEA, > 5.0/≤ 5.0	0.823	-		0.068	-		0.289	-		0.612	-
Adjuvant chemotherapy, ≥ 6 months/< 6 months	0.001b	0.370 (0.222-0.618)	< 0.001c	0.527	-		0.002b	0.332 (0.164-0.672)	0.002b	0.127	-

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

P₁: Univariate P value; P₂: Multivariate P value; PD: Pancreaticoduodenectomy; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; AJCC: American Joint Committee on Cancer; PNI: Perineural invasion; PVI: Perivascular invasion.