Different lymph node staging systems for predicting the prognosis of colorectal neuroendocrine neoplasms

Table 2 The association of positive lymph node, lymph node ratio, and log odds of positive lymph nodes on the prognosis of colorectal neuroendocrine neoplasms treated surgically

Variables	Model 11	P value	Model 22	P value	Model 33	P value
	HR (95%CI)		HR (95%CI)		HR (95%CI)
PLN staging
Tile 1 (< 5)	Ref		Ref		Ref
Tile 2 (5-10)	1.10 (0.83-1.45)	0.526	1.28 (0.96-1.70)	0.090	1.14 (0.84-1.56)	0.400
Tile 3 (≥ 10)	3.67 (2.85-4.73)	< 0.001	3.56 (2.76-4.59)	< 0.001	2.05 (1.54-2.74)	< 0.001
LNR staging
Tile 1 (< 0.30)	Ref		Ref		Ref
Tile 2 (0.30-0.65)	1.43 (1.10-1.87)	0.008	1.67 (1.28-2.19)	< 0.001	1.54 (1.15-2.07)	0.004
Tile 3 (≥ 0.65)	4.49 (3.48-5.81)	< 0.001	4.48 (3.46-5.79)	< 0.001	2.98 (2.21-4.01)	< 0.001
LODDS staging
Tile 1 (< 0.47)	Ref		Ref		Ref
Tile 2 (0.47-1.59)	1.34 (1.02-1.76)	0.039	1.56 (1.18-2.06)	0.002	1.47 (1.09-1.99)	0.013
Tile 3 (≥ 1.59)	4.42 (3.44-5.68)	< 0.001	4.36 (3.38-5.61)	< 0.001	3.03 (2.26-4.05)	< 0.001

¹Model 1: Coarse model.

²Model 2: Adjusted gender and age.

³Model 3: Adjusted gender, age, marital status, primary tumor site, grade stage, tumor stage, metastasis stage, tumor size, perineural invasion, carcinoembryonic antigen, and chemotherapy.

PLN: Positive lymph node; LNR: Lymph node ratio; LODDS: Log odds of positive lymph nodes; HR: Hazard ratio; CI: Confidence interval.