Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis

Figure 4 Forest plot of the pooled successful gastric cancer organoids culture rate according to different subgroups. A: Gastric cancer organoids (GCOs) from female and male showed the success rate of 67.0, 95% confidence interval (CI): 31.1-95.7, and 46.7%, 95%CI: 31.5-62.2; B: GCOs from surgery or endoscopic submucosal dissection and biopsy showed a pooled success rate of 70.9%, 95%CI: 49.8-88.7 and 53.7%, 95%CI: 27.1-79.5; C: GCOs of poor-differentiated, moderate-differentiated and signet-ring cell cancer showed a pooled success establishment rate of 64.6, 95%CI: 46.0-81.3, 31.0, 95%CI: 6.3-61.3 and 32.7, 95%CI: 0.6-76.7; D: GCOs with pathological tumor-node-metastasis (pTNM) I-II and pTNM stage III-IV stage showed a pooled success establishment rate of 38.3, 95%CI: 4.1-79.1 and 65.2, 95%CI: 45.7-82.7. ES: Effect size; CI: Confidence interval.