Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

Figure 8 prion protein testis specific acted as a sponge for zinc finger protein 184 to inhibit it and activated the expression of homeodomain interacting protein kinase 2. A: Anti-zinc finger protein 184 (ZNF184) RNA immunoprecipitation assays were performed after HCT116/L cells were transfected with prion protein testis specific (PRNT)-negative control (NC) or PRNT-mimics; B: Relative luciferase activities were evaluated after HCT116/L cells were transfected with homeodomain interacting protein kinase 2 (HIPK2)- wild-type or HIPK2- mutant and ZNF184 NC or ZNF184 mimics. ^cP < 0.001. PRNT: Prion protein testis specific; NC: Negative control; ZNF184: Zinc finger protein 184; HIPK2: Homeodomain interacting protein kinase 2; RIP: RNA immunoprecipitation.