Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

Figure 1 Differential expression analysis of oxaliplatin resistance-related genes in the Gene Expression Omnibus database. A: Volcano plot of the oxaliplatin resistance-related genes showing differential expression between oxaliplatin-sensitive and oxaliplatin-resistant groups; B: Heatmap of oxaliplatin resistance-related genes; C: Protein-protein interaction of oxaliplatin resistance-related genes; D: Hub genes of the oxaliplatin resistance-related genes; E: Heatmap of the correlation between oxaliplatin resistance-related genes and long noncoding RNAs; F: Scatter plot of the correlation between prion protein testis specific (PRNT) and homeodomain interacting protein kinase 2 (HIPK2); G: Venn plot of PRNT-related TFs and HIPK2-related TFs; H: Canonical ZNF184 binding motif via Joint Analysis of the Structural Parameters of Analytical Regulation (JASPAR); I: The binding sites of HIPK2 and ZNF184 predicted via JASPAR. PRNT: Prion protein testis specific; ZNF184: Zinc finger protein 184; HIPK2: Homeodomain interacting protein kinase 2.