Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506

Figure 5 Human β-defensin-1 inhibits phosphorylated mTOR expression in SW620 cells. A: Western blot analysis demonstrated that the addition of MHY1485 (mTOR activator) increased p-mTOR (Ser2448) expression and reduced Beclin-1 and LC3II/I expression in SW620 cells; B-D: Relative expression of p-mTOR, Beclin-1, and LC3II/I. ^aP < 0.05 vs control group; ^bP < 0.05 vs human β-defensin-1 group; ^cP < 0.05 vs MHY1485 group. P < 0.05 was considered statistically significant.