MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

Figure 2 MicroRNA-298 overexpression decreases radio-sensitivity in the tumor of ectopic colorectal cancer model. A and B: Mice were treated with ionizing radiation when tumor volume reached 20 mm³, and then tumor growth was monitored for 12 d. Data are mean ± SD values from 5 individual mice in each group. Tumor weights were measured after mice were sacrificed on day 20, representative tumors from corresponding treatments groups. The control group (A) was more sensitive to radiation than the microRNA-298 overexpression group (B). ^aP < 0.05; NS: Not significant. miR-298: MicroRNA-298; UT: Untreated; IR: Ionizing radiation.