Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

Figure 3 Effects of curcumin on apoptosis and proliferation and AKT-mTOR pathway proteins. A: After treating BGC-823 and MGC-803 cells with 40 μmol/L curcumin, the proteins involved in apoptosis and proliferation and the AKT-mTOR pathway were detected using western blotting. Curcumin (40 μmol/L) increased the expression of Bax-2 but decreased the expression of Bcl-2, CDK4, and CDK6 and decreased the phosphorylation of Akt, mTOR, and P65 in gastric cancer cells; B: Statistical graph of the western blotting results. The results were obtained from three independent tests. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.