NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

Figure 6 Nicotinamide adenine dinucleotide phosphate oxidase 4 promotes tumorigenesis and metastasis in vivo. A: Volume of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4)-overexpressing RKO and wild-type tumor and measured at indicated time points; B: The representative image of subcutaneous tumors at the end of the experiment (day 28); C: Immunohistochemical staining analysis showing NOX4 and pERK expression in two groups; D: The representative image of metastatic nodes in the mouse lung tissue; E: Hematoxylin-eosin staining of tumor metastasis in mouse lung tissues; F: Quantification of tumor metastasis in lung tissues. ^aP < 0.05, ^bP < 0.01. NOX4: Nicotinamide adenine dinucleotide phosphate oxidase 4.