NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

Figure 1 Identification of dysregulated metabolic genes in tumor tissues. A: Multi-step analysis of metabolic genes in this study; B: Volcano plot showing metabolic differentially expressed genes (DEGs) between tumor and adjacent tissues; C: Box plots showing the top ten metabolic DEGs based on the adjusted P-value; D: Bar plot showing top ten upregulated and downregulated Kyoto Encyclopedia of Genes and Genomes items; E: Pheatmap showing the consensus matrix (k = 3); F and G: Kaplan-Meier curves showing overall survival and progression free interval across three clusters. ^bP < 0.01. GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; NOX4: Nicotinamide adenine dinucleotide phosphate oxidase 4; FC: Fold change; OS: Overall survival; PFI: Progression free interval.