Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

Figure 3 WNT signaling and metabolic phenotypes in MUC5AC-high tumor cells of cholangiocarcinoma. A: Top 40 enriched signaling pathways of the differentially expressed genes in MUC5AC-high cells; B: Relative activity of the WNT signaling pathway among MUC5AC-high, MUC5AC-low, myeloid cells, endothelial cells, fibroblasts, and lymphocytes; C: Violin plots showing relative expression levels of WNT7A, WNT7B, and MMP7 in MUC5AC-high vs MUC5AC-low cholangiocarcinoma (CCA) cells; D: Correlation analysis between the expression of MUC5AC and WNT7B in CCA tumor samples from cohort 10; E: Gene set enrichment analysis plot showing the enrichment of genes from the MUC5AC-high (left) and MUC5AC-low (right) cells in tumor metastasis signaling pathway. The P value and normalized enrichment score are indicated on the plot.