Copyright
©The Author(s) 2024.
World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1626-1646
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1626
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1626
Subgroup | Successful cases | Number of total | Number of study | Success rate (%) | 95%CI | P value | I2 |
Gender | |||||||
Female | 14 | 23 | 4 | 67.0 | 31.1-95.7 | 0.31 | 36.07 |
Male | 22 | 47 | 4 | 46.7 | 31.5-62.2 | ||
Tissue source | |||||||
Endoscopic biopsy | 16 | 32 | 3 | 53.7 | 27.1-79.5 | 0.28 | 37.35 |
Surgery and ESD | 28 | 40 | 4 | 70.9 | 49.8-88.7 | ||
Differentiate type | |||||||
Poor | 27 | 43 | 3 | 64.6 | 46.0-81.3 | 0.106 | 42.54 |
Moderate | 5 | 15 | 2 | 31.0 | 6.3-61.3 | ||
SRCC | 6 | 16 | 4 | 32.7 | 0.6-76.7 | ||
pTNM | |||||||
I-II | 3 | 8 | 2 | 38.3 | 4.1-79.1 | 0.108 | 42.54 |
III-IV | 18 | 28 | 65.2 | 45.7-82.7 | |||
Enzyme | |||||||
Liberase TH, TrypLE | 47 | 67 | 2 | 71.5 | 59.3-82.3 | 0.04 | 69.27 |
EDTA, DL-dithiothreitol | 34 | 68 | 1 | 50.0 | 37.6-62.4 | ||
Collagenase | 30 | 46 | 3 | 72.1 | 44.4-93.6 | ||
Growth factor | |||||||
B27 | 103 | 152 | 3 | 68.7 | 46.9-83.3 | 0.94 | 90.53 |
Non-B27 | 55 | 77 | 3 | 69.5 | 45.2-87.8 | ||
N-acetylcysteine | 111 | 162 | 4 | 71.9 | 38.2-96.2 | 0.95 | 90.52 |
Non-N-acetylcysteine | 47 | 67 | 2 | 71.5 | 59.3-82.3 | ||
Gastrin | 111 | 162 | 4 | 71.9 | 38.2-96.2 | 0.95 | 90.53 |
Non-gastrin | 47 | 67 | 2 | 71.5 | 59.3-82.3 | ||
FGF-2 | 93 | 134 | 3 | 67.4 | 21.6-99.2 | 0.98 | 90.53 |
Non-FGF-2 | 65 | 95 | 3 | 67.9 | 49.2-84.2 | ||
Nutlin-3 | 47 | 67 | 2 | 71.5 | 59.3-82.3 | 0.95 | 90.53 |
Non-nutlin-3 | 111 | 162 | 4 | 71.9 | 38.2-96.2 | ||
Y-27632 | 21 | 36 | 2 | 58.2 | 41.6-75.0 | 0.505 | 90.53 |
Non-Y-27632 | 137 | 193 | 4 | 70.0 | 39.8-93.3 |
- Citation: Jiang KL, Wang XX, Liu XJ, Guo LK, Chen YQ, Jia QL, Yang KM, Ling JH. Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(4): 1626-1646
- URL: https://www.wjgnet.com/1948-5204/full/v16/i4/1626.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i4.1626