Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis

Table 3 The growth factor applied in the gastric cancer organoids culture

Ref.	Wnt	R-spondin-1	Noggin	B27	EGF	FGF-10	N-acetylcystenine	Gastrin	A83-01	FGF-2	IGF-1	Nicotinamide	Noggin	Nutlin-3	Y-27632	HGF	Other
Tong et al[37]	+	+	+	+	+	+	+	+	+	+			+
Steele et al[24]	+	+	+		+	+	+	+	+				+		+	+	SB202190, p38, MAPK inhibitor, prostaglandin E2
Nanki et al[23]	+	+	+		+	+			+				+	+
Yan et al[21]	+	+	+	+	+	+	+	+	+	+			+
Li et al[25]	+	+	+	+	+	+	+	+	+			+	+		+
Kawasaki et al[22]	+	+	+		+	+			+	+	+		+	+		+	GDNF, DAPTγ-secretase inhibitor and Palbociclib CDK4/CDK6 selective inhibitor
Togasaki et al[28]	+	+	+		+	+			+
Seidlitz et al[30]	+	+	+	+	+	+	+	+	+			+
Gao et al[31]	+	+	+		+	+		+	+			+					Hamburg, TGF, rho-associated
Bartfeld et al[32]	+	+	+		+	+		+	+			+					Hamburg, TGF, rho-associated
Wang et al[33]	+	+	+		+	+			+			+	+		+	+	Prostaglandin E2, SB202190
Kumar et al[34]	+	+	+		+	+		+	+			+	+		+	+	Prostaglandin E2, SB202190
Harada et al[35]	+	+	+	+	+	+	+		+			+	+		+		SB203580
Ukai et al[36]	+	+	+	+	+	+	+		+			+	+		+		SB203580
Yamaguchi et al[38]	+	+		+	+	+	+	+				+			+		TGF-βi

EGF: Epidermal growth factor; FGF: Fibroblast growth factor; IGF-1: Insulin-like growth factors-1; HGF: Hepatocyte growth factor; GDNF: Glialcellline-derived neurotrophic factor; TGF: Transforming growth factor.