Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer: A systematic review and meta-analysis

Table 2 Subgroup analysis, the impact of heat shock protein on 3-year overall survival, grade of cellular differentiation, and tumor-node-metastasis stage in esophageal squamous cell carcinoma

HSP		Overall survivall	Grade of cellular differentiation	T	N	M
CHIP	RD (95%CI)	0.03 (-0.09 to 0.15)	-	-	0.00 (0.00-0.00)	-
	Studies	1	-	-	1	-
HSF1	RD (95%CI)	-0.22 (-0.32 to -0.12)1	0.04 (-0.09 to 0.17)	-0.22 (-0.51 to 0.06)	-0.16 (-0.29 to -0.04)1	0.01 (-0.06 to 0.08)
	Studies	2	2	1	2	1
HSP20	RD (95%CI)	0.16 (-0.12 to 0.45)	0.03 (-0.05 to 0.11)	0.01 (-0.13 to 0.16)	-0.04 (-0.22 to 0.14)	0.00 (0.15 to -0.15)
	Studies	6	7	6	7	4
HSP40	RD (95%CI)	0.22 (0.09-0.35)1	0.03 (-0.10 to 0.16)	-0.04 (-0.14 to 0.06)	0.18 (0.03-0.33)1	0.03 (-0.05 to 0.11)
	Studies	1	1	1	1	1
HSP60	RD (95%CI)	0.33 (0.17-0.50)1	-0.03 (-0.20 to 0.13)	0.09 (-0.09 to 0.26)	-0.04 (-0.21 to 0.14)	0.07 (-0.06 to 0.20)
	Studies	1	1	1	1	1
HSP70	RD (95%CI)	0.07 (-0.18 to 0.31)	-0.08 (-0.17 to 0.00)	-0.07 (-0.25 to 0.11)	-0.17 (-0.45 to 0.12)	-0.10 (-0.33 to 0.12)
	Studies	8	8	6	8	5
HSP90	RD (95%CI)	0.03 (-0.23 to 0.29)	-0.02 (-0.06 to 0.03)	-0.10 (-0.20 to 0.01)	-0.24 (-0.74 to 0.26)	0.18 (-0.18 to 0.54)
	Studies	3	2	4	3	3

¹Significant values.

RD: Risk difference; CI: Confidence interval; HSP: Heat shock protein; HSF: Heat shock factor.