Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer: A systematic review and meta-analysis

Table 1 Characteristics of included studies

Ref.	Cancer type	N	HSP	Age (yr)	Male (%)	Upper third cancer location (%)	Stage III/IV (%)	Follow-up (months)
Akutsu et al[21], 2011	ESCC	78	HSP90	62	89	19	51	24
Berezowska et al[22], 2013	EA and G	347	HSP90	69	64	0	NI	NI
Berg et al[23], 2011	EA	87	HSP20	63	91	0	NI	NI
Doak et al[24], 2004	EA	4	HSP20	63	83	0	NI	NI
Faried et al[25], 2004	ESCC	123	HSP60, 90	61	86	14	38	NI
Huang et al[26], 2014	ESCC	81	HSP90	58	38	0	30	NI
Iqbal et al[27], 2016	ESCC	46	HSP20, 70, 90	58	65	0	16	NI
Kawanishi et al[28], 1999	ESCC	102	HSP20, 70	62	82	NI	36	25
Liao et al[29], 2015	ESCC	134	HSF1	61	81	NI	46	NI
Luz et al[30], 2017	ESCC	28	HSP20, 70	60	82	NI	NI	60
Lv et al[31], 2022	ESCC and EA	87	HSP60	NI	NI	NI	52	NI
Miyazaki et al[32], 2005	ESCC	61	HSP20, 70	65	87	21	49	23
Nakajima et al[33], 2002	ESCC	62	HSP20, 70	61	85	13	42	NI
Nakajima et al[34], 2009	EC	125	HSP70	62	86	14	38	NI
Noguchi et al[35], 2002	ESCC	71	HSP70	64	89	11	45	.
Ou et al[36], 2014	ESCC	328	HSP90	59	82	NI	NI	51
Söderström et al[37], 2019	EA	151	HSP20, 70	65	80	0	83	NI
Tsukao et al[38], 2017	ESCC	212	HSF1, HSP20, 70, 90	65	87	14	54	NI
Wang et al[39], 2007	G	60	HSP70, HSP90	46	53	0	NI	NI
Wang et al[40], 2010	ESCC	120	HSP70, 90	57	77	NI	NI	NI
Wen et al[41], 2013	ESCC	234	CHIP	58	83	10	NI	18
Xue et al[42], 2014	ESCC	112	HSP20	60	54	NI	NI	NI
Yu et al[43], 2015	ESCC	72	HSP40	65	82	NI	66	NI
Zhang et al[44], 2013	ESCC	120	HSP70	53	75	29	36	60
Zhang et al[45], 2017	ESCC	162	HSP20	63	67	NI	NI	NI
Zhang et al[46], 2020	ESCC	345	HSP20	NI	69	NI	NI	NI
Zhao et al[47], 2015	ESCC	113	HSP70	58	82	20	74	NI

HSP: Heat shock protein; ESCC: Esophageal squamous cell carcinoma; G: Gastric; EC: Esophageal cancer; EA: Esophageal adenocarcinoma; NI: Not informed; HSF: Heat shock factor.