NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

doi:10.4251/wjgo.v16.i4.1421

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1421-1436
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1421

Table 2 Three genes obtained from the intersection of differential genes and prognostic genes in colorectal cancer

Gene symbol	Log FC	HR	Function
NOX4	2.868242	1.197865	Constitutive NADPH oxidase which generates superoxide intracellularly
BGN	2.368592	1.259598	May be involved in collagen fiber assembly
PPAPDC1A	2.345055	1.126713	Magnesium-independent phospholipid phosphatase with broad substrate specificity

NOX4: Nicotinamide adenine dinucleotide phosphate oxidase 4; NADPH: Nicotinamide adenine dinucleotide phosphate; FC: Fold change; HR: Hazard ratio.

Citation: Xu YJ, Huo YC, Zhao QT, Liu JY, Tian YJ, Yang LL, Zhang Y. NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer. World J Gastrointest Oncol 2024; 16(4): 1421-1436
URL: https://www.wjgnet.com/1948-5204/full/v16/i4/1421.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i4.1421