Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

doi:10.4251/wjgo.v16.i4.1361

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1361-1373
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1361

Table 5 Performance characteristics of the syndecan-2 methylation test regarding detection of colorectal neoplasia

Category	Colonoscopy (N = 1035)	mSDC2 test (N = 1035)		PPV % (95%CI)	NPV % (95%CI)
Category	Colonoscopy (N = 1035)	Positive (n = 87)	Sensitivity % (95%CI)	PPV % (95%CI)	NPV % (95%CI)
Colorectal cancer	16	14	87.50 (60.41-97.80)	16.09 (9.38-25.87)	99.79 (99.15-99.96)
Advanced adenoma	65	26	40.00 (28.28-52.90)	29.89 (20.78-40.79)	95.89 (94.37-97.02)
Advanced colorectal neoplasia	81	40	49.38 (38.19-60.64)	45.98 (35.36-56.96)	95.68 (94.13-96.84)
		Negative (n = 948)	Specificity % (95%CI)
Others	615	588	95.61 (93.59-97.03)
Others, polyps and NAA	954	907	95.07 (93.45-96.32)
Normal	552	527	95.47 (93.29-96.99)

mSDC: Syndecan-2 methylation; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; Others: Totally normal colonoscopy, colitis and colonic diverticulum, etc.; Polyps: Non-adenomatous polyps; NAA: Non-advanced adenoma; Normal: Totally normal colonoscopy.

Citation: Luo WF, Jiao YT, Lin XL, Zhao Y, Wang SB, Shen J, Deng J, Ye YF, Han ZP, Xie FM, He JH, Wan Y. Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population. World J Gastrointest Oncol 2024; 16(4): 1361-1373
URL: https://www.wjgnet.com/1948-5204/full/v16/i4/1361.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i4.1361