Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

Table 4 Risk factors for detection of advanced colorectal neoplasia

Characteristics	B	SE	Wald	df	P value	OR	95%CI
							Lower limit	Upper limit
Gender
Male	-0.768	0.294	6.816	1	0.009b	0.464	0.261	0.826
Age
40-49			22.792	3	< 0.001c
50-59	-2.627	0.567	21.459	1	< 0.001c	0.072	0.024	0.220
60-69	-1.612	0.499	10.422	1	0.001c	0.200	0.075	0.531
70-79	-1.266	0.516	6.010	1	0.014a	0.282	0.102	0.776
mSDC2
Positive	-2.798	0.320	76.308	1	< 0.001c	0.061	0.033	0.114
Family history of CRC
Yes	-1.674	0.530	9.958	1	0.002b	0.188	0.066	0.530
History of colorectal polyps
Yes	2.055	0.580	12.560	1	< 0.001c	7.809	2.506	24.335
History of chronic diarrhea
Yes	0.077	0.405	0.036	1	0.850	1.080	0.488	2.388
History of chronic constipation
Yes	0.417	0.399	1.090	1	0.296	1.518	0.694	3.320
History of hematochezia
Yes	0.322	0.442	0.529	1	0.467	1.380	0.580	3.284
History of appendicitis
Yes	0.860	0.818	1.105	1	0.293	2.362	0.476	11.729
History of cholecystitis
Yes	-0.306	0.555	0.305	1	0.581	0.736	0.248	2.183
History of psychiatric trauma
Yes	1.287	0.912	1.991	1	0.158	3.621	0.606	21.633

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

CI: Confidence interval; B: Beta; SE: Standard error; df: Degree of freedom; OR: Odds ratio; CRC: Colorectal cancer; mSDC: Syndecan-2 methylation.