Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

doi:10.4251/wjgo.v16.i4.1361

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1361-1373
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1361

Table 2 Primary outcomes of pathological findings on screening

Characteristics	Intestinal lesions (N%)				Others (N%)	P value
Characteristics	CRC	AA	NAA	Polyps	Others (N%)	P value
Gender						< 0.001^a
Male	9 (0.87)	43 (4.15)	109 (10.53)	77 (7.44)	264 (25.51)
Female	7 (0.68)	22 (2.13)	80 (7.73)	73 (7.05)	351 (33.91)
Age (yr)						< 0.001^a
40-49	3 (0.29)	8 (0.77)	48(4.64)	46 (4.44)	268 (25.89)
50-59	5 (0.48)	30 (2.90)	73 (7.05)	59 (5.70)	239 (23.09)
60-69	7 (0.68)	18 (1.74)	57 (5.51)	38 (3.67)	91 (8.79)
70-79	1 (0.10)	9 (0.87)	11 (1.06)	7 (0.68)	17 (1.64)
mSDC2						< 0.001^a
Positive	14 (1.35)	26 (2.51)	8 (0.77)	12 (1.16)	27 (2.61)
Negative	2 (0.19)	39 (3.77)	181 (17.49)	138 (13.33)	588 (56.81)

^aP < 0.001.

mSDC: Syndecan-2 methylation; CRC: Colorectal cancer; AA: Advanced adenoma; NAA: Non-advanced adenoma; Polyps: Non-adenomatous polyps; Others: Totally normal colonoscopy, colitis and colonic diverticulum, etc.

Citation: Luo WF, Jiao YT, Lin XL, Zhao Y, Wang SB, Shen J, Deng J, Ye YF, Han ZP, Xie FM, He JH, Wan Y. Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population. World J Gastrointest Oncol 2024; 16(4): 1361-1373
URL: https://www.wjgnet.com/1948-5204/full/v16/i4/1361.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i4.1361