Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

Table 1 Baseline data of subjects evaluated

Characteristics	Cases (N%)	mSDC2 (N%)		P value
		(+) n = 87	(-) n = 948
Gender				0.028a
Male	502 (48.50)	52 (5.02)	450 (43.48)
Female	533 (51.50)	35 (3.38)	498 (48.12)
Age				< 0.001b
40-49	373 (36.04)	15 (1.45)	358 (34.59)
50-59	406 (39.22)	39 (3.77)	367 (35.46)
60-69	211 (20.39)	25 (2.42)	186 (17.97)
70-79	45 (4.35)	8 (0.77)	37 (3.57)
Family history of CRC				< 0.001b
Yes	99 (9.57)	18 (1.74)	81 (7.83)
No	936 (90.43)	69 (6.67)	867 (83.77)
History of colorectal polyps				0.406
Yes	252 (24.35)	18 (1.74)	234 (22.61)
No	783 (75.65)	69 (6.67)	714 (68.99)
History of chronic diarrhea				0.108
Yes	342 (33.04)	22 (2.13)	320 (30.92)
No	693 (66.96)	65 (6.28)	628 (60.68)
History of chronic constipation				0.747
Yes	493 (47.63)	40 (3.86)	453 (43.77)
No	542 (52.37)	47 (4.54)	495 (47.83)
History of hematochezia				0.692
Yes	580 (56.04)	47 (4.54)	533 (51.50)
No	455 (43.96)	40 (3.86)	415 (40.10)
History of appendicitis				0.243
Yes	66 (6.38)	3 (0.29)	63 (6.09)
No	969 (93.62)	84 (8.12)	885 (85.51)
History of cholecystitis				0.836
Yes	66 (6.38)	6 (0.58)	60 (5.80)
No	969 (93.62)	81 (7.83)	888 (85.80)
History of psychiatric trauma				0.890
Yes	63 (6.09)	5 (0.48)	58 (5.60)
No	972 (93.91)	82 (7.92)	890 (85.99)
Pathological classification				< 0.001b
CRC	16 (1.55)	14 (1.35)	2 (0.19)
AA	65 (6.28)	26 (2.51)	39 (3.77)
NAA	189 (18.26)	8 (0.77)	181 (17.49)
Polyps	150 (14.49)	12 (1.16)	138 (13.33)
Others	615 (59.42)	27 (2.61)	588 (56.81)

^aP < 0.05.

^bP < 0.001.

mSDC: Syndecan-2 methylation; CRC: Colorectal cancer; AA: Advanced adenoma; NAA: Non-advanced adenoma; Polyps: Non-adenomatous polyps; Others: Totally normal colonoscopy, colitis and colonic diverticulum, etc.