Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

Table 5 Cox proportional hazard regression analysis of the prognostic factors of cancer

Variable	Univariate Cox analysis1		Multivariate Cox analysis1		Univariate Cox analysis2		Multivariate Cox analysis2
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age ≥ 65 yr	0.907 (0.646-1.286)	0.586	0.805 (0.557-1.164)	0.25	1.205 (0.852-1.705)	0.293	1.142 (0.795-1.640)	0.473
Gender	0.977 (0.677-1.408)	0.899	0.823 (0.560-1.209)	0.32	0.927 (0.643-1.338)	0.687	0.869 (0.523-1.443)	0.588
TNM staging	1.371 (0.715-2.625)	0.342	0.945 (0.651-1.374)	0.769	1.614 (0.816-3.194)	0.169	1.372 (0.666-2.826)	0.391
Treatment line	0.794 (0.552-1.141)	0.213	1.591 (0.794-3.186)	0.19	0.992 (0.686-1.433)	0.965	0.924 (0.636-1.341)	0.677
Her-2 expression	1.001 (0.620-1.617)	0.996	1.045 (0.634-1.723)	0.863	0.815 (0.495-1.341)	0.421	0.988 (0.678-1.439)	0.949
irAEs	0.609 (0.431-0.863)	0.005	0.608 (0.431-0.863)	0.006	0.735 (0.520-1.039)	0.081	0.761 (0.535-1.083)	0.129

¹Progression-free survival.

²Overall survival.

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; Her-2: Human epidermal growth receptor 2; irAEs: Immune-related adverse reactions.