Esophageal cancer screening, early detection and treatment: Current insights and future directions

Table 2 The pros and cons of diagnostic and therapeutic protocols in esophageal carcinoma

Diagnostic and therapeutic protocols	Indications	Pros	Cons
(1) For patients with early-stage EC who meet the absolute and relative indications for endoscopic resection, ESD being the first choice; (2) When the long diameter of the lesion is ≤ 10 mm, if the whole piece can be guaranteed resection, EMR treatment can also be considered; (3) For patients with early-stage EAC after EMR resection, ablation treatment is recommended; (4) Endoscopic radiofrequency ablation (RFA) can be used to treat ESCC limited to the lamina propria of the mucosa; and (5) For patients with lesions infiltrating to a depth of submucosal (> 200 μm) T1b stage EC patients with lymph node or vascular invasion and tumor low differentiation (≥ G3), esophagectomy should be performed. Those who refuse surgery or are intolerant to surgery should be treated with concurrent radiotherapy and chemotherapy[26]	(1) The absolute indication of endoscopic resection of EC is that the lesion is limited to the epithelial layer and lamina propria of T1a esophageal cancer, and the risk of lymph node metastasis is low; (2) The relative indications of endoscopic resection: the lesion extends to the muscularis mucosa or slightly infiltrates the submucosa (the depth of submucosal infiltration is less than 200 μm), the range is ≥ 3/4 of esophageal circumference, and the risk of stenosis after resection is high. However, patients should be fully informed of postoperative stenosis and other risks; (3) Lesions with infiltration depths (> 200 μm) up to the submucosal layer (T1b) are associated with metastasis, in which case they should be treated in the same way as advanced cancers, even if they are classified as superficial[26,55]	(1) EMR: Easy to operate and less invasive. Short operation time, low risk and quick recovery; (2) ESD: Larger tumors, especially those larger than 2 cm in diameter, can be completely removed at once, reducing the likelihood of recurrence; (3) RFA has a relatively short recovery time and demonstrates a low recurrence rate; (4) Surgery: Completely remove the tumor, thereby reducing the risk of recurrence, and providing exact pathological staging information, which helps to assess the progression of the cancer and plan subsequent treatment; and (5) CRT: Providing good local lesion control and helping to reduce tumor size, which may make surgery easier or, in some cases, avoid it; being effective in reducing the rate of tumor recurrence for some patients; and making CRT an effective treatment option for patients who can't afford to have surgery due to health issues	(1) EMR: Difficulty in removing large or poorly defined tumors at one time, which may require multiple treatments and a relatively high rate of recurrence; (2) Technically demanding, the procedure takes longer and may increase the risk of complications, such as bleeding or perforation; (3) RFA: Narrow range of indications; may increase risks and complications, include pain, bleeding, esophageal stricture or perforation, requiring specialized equipment and trained physicians; (4) Surgery: There are risks associated with the surgery itself (e.g., infection, bleeding, anesthesia complications, etc.), possible postoperative complications (e.g., esophageal stricture, dysphagia, malnutrition, etc.), and negative impact on the patient's quality of life, especially in terms of digestive function and eating habits. In addition, the long postoperative recovery time may require additional nutritional support and rehabilitation; and (5) CRT: Include a wide range of possible side effects from chemotherapy and radiation (e.g., nausea, vomiting, hair loss, fatigue, loss of appetite, etc.); the potential for a long-term decline in quality of life, such as digestive problems and difficulty swallowing; and the potential for a wide-ranging impact on a patient's overall health status, especially for patients who are older or who have other health problems

EC: Esophageal carcinoma; ESD: Endoscopic submucosal dissection; EMR: Endoscopic mucosal resection; CRT: Concurrent radiotherapy; RFA: Radiofrequency ablation.