Copyright
©The Author(s) 2024.
World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1134-1153
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1134
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1134
Methods | Combination | Results | Ref. |
TME modulator + Vaccine + ICI | mAb-AR20.5 + PolyICLC + anti-PD-L1 | Rejection of tumor cells expressing MUC1 and increased cytotoxic activity of CD8+ T cells | [201] |
TME modulator + ICI | TGF-β inhibitor + anti-PD-L1/anti-CTLA-4 | Inhibited tumor growth, improved CD8+ T cell infiltration and increased the population of M1 macrophages in the TME | [202] |
TME modulator + ICI | SLC4A4 inhibitor + anti-PD-1/anti-CTLA-4 | It reduced the acidity of the TME, increased the infiltration of CD8+ T cells and the number of M1 macrophages | [203] |
TME modulator + ICI | MEK and STAT3 inhibitors + anti-PD-1 | Attenuated the pro-inflammatory CAF myofibroblastic phenotypes expressing IL6/CXCL1 and increased the recruitment of CD8+ T cells | [204] |
IL-17 signaling blocker + ICI | Anti-IL17+ anti-IL17R + anti-PD-1/anti-CTLA-4 | Favored the activation of CD8+ T cells, achieved a 50% response rate and increased survival | [205] |
NKT activation + recombinant oncolytic virus + ICI | NKT + VSV-IL-15 + anti-PD-1 | It increased overall tumor regression, survival time, NK/T CD8 cell infiltration and resulted in complete tumor elimination in 20% of the mice | [206] |
Vaccine + ICI + TME modulator + chemotherapy | GVAX + anti-PD-1 + anti-CSF-1R + gemcitabine | It increased the number of infiltrated CD8+T cells, reduced the infiltration of myeloid cells, myeloid-derived suppressor cells and reduced the number of TAMs | [207] |
- Citation: Silva LGO, Lemos FFB, Luz MS, Rocha Pinheiro SL, Calmon MDS, Correa Santos GL, Rocha GR, de Melo FF. New avenues for the treatment of immunotherapy-resistant pancreatic cancer. World J Gastrointest Oncol 2024; 16(4): 1134-1153
- URL: https://www.wjgnet.com/1948-5204/full/v16/i4/1134.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i4.1134