Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

Figure 6 The expression of mitochondrial carrier homolog 2 and ATP2A2 is involved in the malignant phenotype of gastric epithelial cells and the metastasis of human gastric cancer cells. A-G: After mitochondrial carrier homolog 2 (MTCH2)-OE plasmid was transfected into gastric epithelial cells, changes of the expression level of MTCH2, ATP2A2, Vimentin, β-catenin, N-cadherin, and E-cadherin were detected; H-N: After human gastric cancer cells (AGS) were transfected with MTCH2-OE, MTCH2 siRNA3 and MTCH2 siRNA2, the expression level of MTCH2, ATP2A2, Vimentin, β-catenin, N-cadherin, and E-cadherin were detected by Western blotting; O-T: After AGS cells were transfected with MTCH2-siRNA or ATP2A2 siRNA, the expression level of MTCH2, ATP2A2, Vimentin, β-catenin, and N-cadherin were detected by Western blotting. NS: No significant; ^aP < 0.001, compared with NC-OE; ^bP < 0.001, ^cP < 0.001, compared with NC-siRNA; ^dP < 0.001, ^eP < 0.001, ^fP < 0.001, ^hP < 0.05, compared with MTCH2 siRNA + ATP2A2 siRNA; ^gP < 0.001, compared with ATP2A2 siRNA.