Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

Figure 4 Mitochondrial carrier homolog 2 regulates the level of mitochondrial membrane potential. A and C: Mitochondrial membrane potential level of human gastric mucosal cell and human gastric cancer cells were detected by JC-1 staining; B and D: Quantification of JC-1 fluorescence intensity (scale bar: 50 μm). MTCH2: Mitochondrial carrier homolog 2; siRNA: Small interfering RNA; OE: Overexpression; NC-OE: Negative control of overexpression; NC-siRNA: Negative control of siRNA; GES-1: Human gastric mucosal cell; AGS: Human gastric cancer cells. ^aP < 0.001, compared with positive control; ^bP < 0.001, compared with NC-OE; ^cP < 0.001, compared with NC-siRNA.