Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

Figure 3 Mitochondrial carrier homolog 2 regulates mitochondrial ATP production. A and C: ATP concentration of human gastric mucosal cell (GES-1) and human gastric cancer cells (AGS) were detected through pcMV-AT1.03 plasmid transfection; B and D: Quantification of ATP fluorescence intensity (scale bar: 50 μm); E and G: Detection of the proliferation of GES-1 and AGS cells after by colony formation assay; F and H: Number of cell colonies in different groups. MTCH2: Mitochondrial carrier homolog 2; siRNA: Small interfering RNA; OE: Overexpression; NC-OE: Negative control of overexpression; NC-siRNA: Negative control of siRNA; GES-1: Human gastric mucosal cell; AGS: Human gastric cancer cells. ^aP < 0.05, ^bP < 0.001 compared with NC-OE; ^cP < 0.001, compared with NC-siRNA.