Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

Figure 2 Effects of mitochondrial carrier homolog 2 on invasion and migration of human gastric mucosal cells and human gastric cancer cells. A and C: Migration of human gastric mucosal cell (GES-1) and human gastric cancer cells (AGS) was detected by scratch wound healing assay; B and D: Ratio of 24 h to 0 h wound distance, (scale bar: 400 μm); E and G: Invasion ability of GES-1 and AGS cells was detected by transwell; F and H: The number of cells invaded in random fields of view (scale bar: 50 μm). MTCH2: Mitochondrial carrier homolog 2; siRNA: Small interfering RNA; OE: Overexpression; NC-OE: Negative control of overexpression; NC-siRNA: Negative control of siRNA; GES-1: Human gastric mucosal cell; AGS: Human gastric cancer cells. ^aP < 0.01, ^bP < 0.001, compared with NC-OE; ^cP < 0.001, compared with NC-siRNA.