Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

Figure 1 The expression difference of mitochondrial carrier homolog 2 in gastric cancer and paracancer tissues. A: Gene Expression Profiling Interactive Analysis (GEPIA) was used to analyze the expression of mitochondrial carrier homolog 2 (MTCH2) (left) and MTCH1 (right) in stomach adenocarcinoma; B-D: Expression of MTCH2 and ATP2A2 in gastric cancer tissues and paracarcinoma tissues, n = 65; E-J: MTCH2-OE and MTCH2-siRNA transfection were validated by Western blotting (scale bar: 50 μm). MTCH: Mitochondrial carrier homolog; STAD: Stomach adenocarcinoma; GES-1: Human gastric epithelial cells; AGS: Human gastric cancer cells. ^aP < 0.001, compared with gastric cancer; ^bP < 0.001, compared with NC-OE; ^cP < 0.001, ^dP < 0.001, compared with NC-siRNA.