N-glycan biosignatures as a potential diagnostic biomarker for early-stage pancreatic cancer

Figure 2 N-glycome profile from desialylated serum. A: Typical desialylated N-glycan profiles from the total serum protein in patients with pancreatic ductal adenocarcinoma (PDAC), patients without PDAC, and healthy participants; B: Structure of nine N-glycan peaks (GPs). GP1 indicates an agalacto core α-1,6 fucosylated biantennary glycan (NGA2F), GP2 indicates an agalacto core α-1,6 fucosylated bisecting bian tennary glycan (NGA2FB), GP3 and GP4 indicate a single agalacto core α-1,6 fucosylated biantennary glycan (NG1A2F), GP5 indicates a bigalacto biantennary glycan (NA2), GP6 indicates a bigalacto core α-1,6 fucosylated biantennary glycan (NA2F), GP7 indicates a bigalacto core α-1,6 fucosylated bisecting biantennary glycan (NA2FB), GP8 indicates a triantennary glycan (NA3), and GP9 indicates a branching α-1,3 fucosylated triantennary glycan (NA3Fb); C: N-glycan analysis in the three groups of patients. ^aP < 0.05, ^bP < 0.01. GPs: Glycan peaks; PDAC: Pancreatic ductal adenocarcinoma.