Roles and application of exosomes in the development, diagnosis and treatment of gastric cancer

Figure 1 The biogenesis and release of exosomes. Exosomes form early endosomes in the cell membrane and then transform into multivesicular bodies, which are fused with the cell membrane and released into the extracellular matrix. Exosomes enter target cells in three ways: Direct fusion, endocytosis and protein receptor interaction. ER: Endoplasmic reticulum; ILV: Intraluminal vesicle; MVBs: Multivesicular bodies; MHC: Major histocompatibility complex; PRGL: Proteoglycan; TSG101: Tumor susceptibility gene 101; miRNA: MicroRNA; ALIX: ALG2-interacting protein X; TAA: Target-associated antigen; PD-L1: Programmed cell death-ligand 1; FasL: Fas ligand.