CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

Figure 3 CALD1 gene is associated with PI3K-Akt-mTOR and epithelial-mesenchymal transition pathways in gastric cancer: Insights from bioinformatics and protein interaction studies. A: Bioinformatics results showed that the CALD1 gene was significantly associated with the expression of members in the PI3K-Akt-mTOR signaling pathway as well as the epithelial-mesenchymal transition signaling pathway in gastric cancer; B: PPI network analysis of CALD1 showed that it interacts with a variety of proteins; C: GO and KEGG enrichment analyses showed that CALD1 was closely associated with the PI3K-Akt signaling pathway; D: In-depth analysis revealed that CALD1 was highly expressed in fibroblasts and was significantly positively correlated with the expression of fibroblast surface molecules.