Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer

Figure 3 The binding of GATA6-AS1 to methylase. A: RIP experiments confirmed that of the three m6A methylases, fat mass and obesity-associated protein, YTH domain-containing family protein 1 and methyltransferase-like 3, GATA6-AS1 bound most strongly to the m6A demethylase fat mass and obesity-associated protein (FTO) in AGS cells; B: RIP experiment performed in HGC-27 cells also demonstrated that GATA6-AS1 has strong binding ability with m6A demethylase FTO. ^aP < 0.05. ^bP < 0.01. FTO: Fat mass and obesity-associated protein; YTHDF1: YTH domain-containing family protein 1; METTL3: Methyltransferase-like 3.