Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

Figure 4 Ubiquitin-specific protease 21 aggravated tumor growth in vivo. Groups were separated into the sh-NC, sh-USP21 and sh-USP21+pcDNA3.1/ZEB1 group. A and B: The tumor size, volume and weight were assessed through in vivo assays; C: The protein expressions of ki67, USP21 and ZEB1 in tumors were measured through immunohistonchemistry assay. ^cP < 0.001. NC: Negative control; USP21: Ubiquitin-specific protease 21.