Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

Table 2 Comparison of relative expression of Wnt1, β-catenin, cyclinD1, epidermal growth factor, and c-Myc m-RNA in each group

Norm	Control group	MNU group	H. pylori + MNU group	Moluodan group	F value	P value
Wnt1	1.10 ± 0.12	3.69 ± 0.16a	4.72 ± 0.06a,b	2.99 ± 0.19a,b,c	347.51	< 0.001
β-catenin	1.03 ± 0.03	2.74 ± 0.11a	3.73 ± 0.12a,b	1.70 ± 0.06a,b,c	523.67	< 0.001
CyclinD1	1.06 ± 0.17	3.22 ± 0.07a	3.84 ± 0.16a,b	2.17 ± 0.11a,b,c	248.70	< 0.001
EGF	1.08 ± 0.07	2.96 ± 0.14a	4.32 ± 0.24a,b	2.17 ± 0.11a,b,c	230.00	< 0.001
c-Myc	1.10 ± 0.14	2.80 ± 0.14a	4.40 ± 0.08a,b	1.97 ± 0.11a,b,c	411.91	< 0.001

^aP < 0.05 vs control group.

^bP < 0.05 vs N-methyl-N-nitrosourea group.

^cP < 0.05 vs Helicobacter pylori + N-methyl-N-nitrosourea group.

EGF: Epidermal growth factor; MNU: N-methyl-N-nitrosourea; H. pylori: Helicobacter pylori.