Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

Table 3 Univariate analysis of cardiovascular disease in hepatocellular carcinoma patients in training test

Characteristics	Labels	HR (95%CI)	P value
Age	< 60	Ref.
	≥ 60	2.054 (1.637-2.576)	< 0.001
Sex	Male	Ref.
	Female	0.872 (0.694-1.095)	0.237
Race	White	Ref.
	Black	1.089 (0.830-1.428)	0.539
	Other	0.653 (0.493-0.864)	0.003
Marital status	Married	Ref.
	Unmarried	1.322 (1.042-1.678)	0.022
	DSW	1.377 (1.099-1.726)	0.006
Year of diagnosis	2010-2011	Ref.
	2012-2013	0.970 (0.764-1.231)	0.802
	2014-2015	1.076 (0.846-1.370)	0.549
AFP	Normal	Ref.
	Elevated	0.786 (0.647-0.954)	0.015
Grade	GradeⅠ	Ref.
	GradeⅡ	0.775 (0.611-0.982)	0.035
	GradeⅢ	1.263 (0.961-1.659)	0.094
	GradeⅣ	0.860 (0.563-1.314)	0.486
Tumor size	≤ 2 cm	Ref.
	2-5 cm	1.361 (1.018-1.821)	0.038
	> 5 cm	2.254 (1.667-3.048)	< 0.001
T stage	T1	Ref.
	T2	0.761 (0.602-0.960)	0.022
	T3	1.110 (0.844-1.460)	0.454
	T4	1.806 (1.033-3.159)	0.038
N stage	N0	Ref.
	N1	0.732 (0.400-1.339)	0.311
M stage	M0	Ref.
	M1	1.039 (0.650-1.662)	0.872
Surgery	No	Ref.
	Yes	0.447 (0.359-0.557)	< 0.001
Radiotherapy	None/unknown	Ref.
	Yes	1.203 (0.877-1.650)	0.253
Chemotherapy	None/unknown	Ref.
	Yes	0.770 (0.637-0.931)	0.007

HR: Hazard ratio; CI: Confidence interval; CVD: Cardiovascular disease; DSW: Divorced, separated, and widowed; AFP: Alpha fetoprotein.