Combining systemic inflammatory response index and albumin fibrinogen ratio to predict early serious complications and prognosis after resectable gastric cancer

Table 6 Univariate and multivariate Cox regression analysis for disease-free survival in gastric cancer patients

Variables		Univariate analysis			Multivariate analysis
		HR	95%CI	P value	HR	95%CI	P value
Age in yr		1.026	1.009-1.043	0.003a	1.005	0.988-1.022	0.589
Tumor dimensions in cm	< 3/≥ 3	2.679	1.772-4.051	< 0.001a	1.165	0.736-1.844	0.514
Differentiation	Moderate and poor/well	0.241	0.060-0.974	0.046a	0.674	0.48-3.056	0.609
Her-2	Negative/positive	2.151	0.247-1.123	0.097	0.563	0.258-1.229	0.149
TNM stage				< 0.001a			< 0.001a
	I	Ref			Ref
	II	2.920	1.546-5.512	0.001a	1.726	0.774-3.850	0.182
	III	5.167	2.844-9.387	< 0.001a	4.071	1.757-9.435	0.001a
Operation time in min		1.003	1.001-1.005	0.014a	1.002	0.999-1.004	0.201
Perioperative transfusion	No/yes	2.288	1.666-3.141	< 0.001a	1.377	0.954-1.989	0.088
CA199 in ng/mL	Negative/positive	1.852	1.292-2.653	0.001a	1.251	0.851-1.838	0.255
CEA in ng/mL	Negative/positive	1.780	1.280-2.476	0.001a	1.234	0.875-1.741	0.231
Lymph node metastasis rate, %		0.998	0.988-1.008	0.698	0.993	0.982-1.005	0.238
Postoperative complication	No or minor/major	3.980	2.895-5.470	< 0.001a	1.604	1.115-2.307	0.011a
Postoperative chemotherapy	No/yes	1.836	1.248-2.702	0.002a	0.609	0.365-1.018	0.059
Lymphocytes as × 109/L		0.515	0.378-0.703	< 0.001a	0.954	0.669-1.359	0.792
Neutrophils as × 109/L		1.192	1.119-1.269	< 0.001a	1.036	0.938-1.144	0.484
Monocyte as × 109/L		5.946	2.457-14.387	< 0.001a	0.980	0.301-3.188	0.973
Albumin in g/L		0.884	0.857-0.912	< 0.001a	0.959	0.920-0.999	0.044a
Fibrinogen in g/L		2.141	1.867-2.456	< 0.001a	1.407	1.126-1.759	0.003a
SIRI		1.142	1.080-1.207	< 0.001a	1.076	0.913-1.268	0.380
AFR		0.735	0.692-0.780	< 0.001a	0.931	0.700-1.239	0.625
SIRI-AFR score							< 0.001a
	0	Ref			Ref
	1	6.042	3.339-10.931	< 0.001a	3.543	1.844-6.809	< 0.001a
	2	18.207	10.138-32.699	< 0.001a	5.005	2.256-11.107	< 0.001a

^aP < 0.05.

AFR: Albumin fibrinogen ratio; CA199: Carbohydrate antigen 199; CEA: Carcinoembryonic antigen; CI: Confidence interval; OR: Odds ratio; SIRI: Systemic inflammation response index; TNM: Tumor-node-metastasis.