Prognostic and predictive role of immune microenvironment in colorectal cancer

Table 2 Studies of immunoscore in different tumor types

Ref.	Tumor	Number of patients, n	Test	Result
Ghiringhelli et al[69], 2023	NSCLC	133	IS-IC	Correlation IS and PFS (HR = 0.39, 95%CI: 0.26-0.59, P < 0.0001), OS (HR = 0.42, 95%CI: 0.27-0.65, P < 0.0001). 36-month PFS IS-high 34%, IS-low 0%
Antoniotti et al[65], 2022	CRC	216	IS-IC	IS-high + ICI - OS HR = 0.39, 95%CI: 0.18-0.84, P < 0.001
Bifulco et al[70], 2014	Melanoma	190	IS-IC	Correlation CD8+, PD-L1- and OS P = 0.04

CI: Confidence interval; CRC: Colorectal cancer; HR: Hazard ratio; ICI: Immune checkpoint inhibitor; IS: Immunoscore; NSCLC: Non-small cell lung cancer; OS: Overall survival; PD-L1: Programmed cell death-ligand 1; PFS: Progression-free survival.