Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Table 1 Pancreatic cyst fluid analysis based on endoscopic ultrasound-fine needle aspiration

Type	SCN	MCN	IPMN	SPTP	Pseudocyst
Viscosity	Low	High	High	NA	Low
Mucin	Low	High	High	NA	Low
Amylase	< 250 U/L	< 250 U/L	High	Low	High
Cytology	Negative or Glyogen containing cuboid cells	Mucin containing column cells	Papillary clusters of mucin column cells, atypia	Branching papillae cuboid or cylindric cells, high cellularity, myxoid stroma	Dirty material, macrophages, inflammatory cell
NGS	VHL; chr3 LOH	CEA	KRAS; GNAS; TP53; PTEN; CEA	CTNNB1	NA

SCN: Serous cystadenoma; MCN: Mucinous cystadenoma; IPMN: Intraductal papillary mucinous neoplasm; SPTP: Solid pseudopapillary tumor of the pancreas; NGS: Next-generation sequencing; LOH: Loss of heterozygosity; CEA: Carcinoembryonic antigen; NA: Not available.